Chromogranin-A production and fragmentation in patients with Takayasu arteritis.
Enrico TombettiBarbara ColomboMaria Chiara Di ChioSilvia SartorelliMaurizio PapaAnnalaura SalernoEnrica Paola BozzoloElisabetta TomboliniGiulia BenedettiClaudia GodiChiara LanzaniPatrizia Rovere-QueriniAlessandro Del MaschioAlessandro AmbrosiFrancesco De CobelliMaria Grazia SabbadiniElena BaldisseraAngelo CortiAngelo A ManfrediPublished in: Arthritis research & therapy (2016)
The plasma levels of CgA fragments are markedly increased in TA as a consequence of disease- and therapy-related variables. Anti-angiogenic forms of CgA may limit vascular remodelling. Given the effect of the various CgA peptides, it is advisable to limit the therapeutic prescriptions that might influence CgA-derived peptide levels to clearly agreed medical indications until further data become available.