The emerging role of GSK-3β in the pathobiology of classical Hodgkin lymphoma.
Claudio AgostinelliSilvia CarloniFrancesco LimarziSimona RighiMaria Antonella LaginestraGerardo MusuracaMichelangelo FiorentinoRoberta NapolitanoAntonio CuneoDaniele VergaraPier Luigi ZinzaniElena SabattiniStefano A PileriSerena De MatteisPublished in: Histopathology (2017)
We demonstrated the activation of GSK-3β in cHL resulting in inhibition of the Wnt/β-catenin signal cascade and the aberrant accumulation of its activated form in nuclei of Hodgkin Reed-Sternberg and Hodgkin cells. These findings may be relevant for future clinical studies, identifying GSK-3β as a potential therapeutic target for cHL.