Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas.

Published in: Endocrinology and metabolism (Seoul, Korea) (2020)

Invasive NFPAs harbor different gene expression profiles relative to noninvasive NFPAs. In particular, local suppression of the immune response and TGF-β signaling can make PAs prone to invasiveness.

Keyphrases

immune response
genome wide
dendritic cells
toll like receptor
copy number
transforming growth factor
gene expression
signaling pathway