Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3.
Zeina SalloumKristin DaunerNeha VermaJohn D ZhangKiran NakkaDavid Valdivieso-GonzálezVíctor Almendro-VediaJeffery McDonaldAlexander SoriskyIván López-MonteroF Jeffrey DilworthXiaohui ZhaPublished in: bioRxiv : the preprint server for biology (2023)
. Bone-marrow derived cells, including macrophages, are highly proliferating and require plasma LDL and cholesterol biosynthesis to provide cholesterol for new membrane production. By lowering the plasma LDL and inhibiting HMG-CoA reductase, statin therapy could generate macrophages with relatively less cholesterol in membranes, including the IMM, thereby promoting JMJD3 expression and anti-inflammatory function. This could contribute at least in part to observed anti-inflammatory effects of statins in human population.
Keyphrases
- low density lipoprotein
- anti inflammatory
- inflammatory response
- cardiovascular disease
- induced apoptosis
- endothelial cells
- oxidative stress
- signaling pathway
- coronary artery disease
- mesenchymal stem cells
- lipopolysaccharide induced
- stem cells
- cell cycle arrest
- lps induced
- cell therapy
- toll like receptor
- bone marrow
- cell wall