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Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3.

Zeina SalloumKristin DaunerNeha VermaJohn D ZhangKiran NakkaDavid Valdivieso-GonzálezVíctor Almendro-VediaJeffery McDonaldAlexander SoriskyIván López-MonteroF Jeffrey DilworthXiaohui Zha
Published in: bioRxiv : the preprint server for biology (2023)
. Bone-marrow derived cells, including macrophages, are highly proliferating and require plasma LDL and cholesterol biosynthesis to provide cholesterol for new membrane production. By lowering the plasma LDL and inhibiting HMG-CoA reductase, statin therapy could generate macrophages with relatively less cholesterol in membranes, including the IMM, thereby promoting JMJD3 expression and anti-inflammatory function. This could contribute at least in part to observed anti-inflammatory effects of statins in human population.
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