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The Enigma of Eosinophil Degranulation.

Timothée FettreletLea GigonAlexander V KaraulovShida YousefiHans-Uwe Simon
Published in: International journal of molecular sciences (2021)
Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • healthcare
  • dendritic cells
  • oxidative stress
  • public health
  • density functional theory
  • signaling pathway
  • cell proliferation
  • molecular dynamics
  • social media