Nitric oxide regulates metabolism in murine stress erythroid progenitors to promote recovery during inflammatory anemia.

Baiye RuanYuanting ChenSara TrimidalImhoi KooFenghua QianJingwei CaiJohn McguiganMolly A HallAndrew D PattersonK Sandeep PrabhuRobert F Paulson

Published in: bioRxiv : the preprint server for biology (2023)

Nitric-oxide (NO) dependent signaling favors an anabolic metabolism that promotes proliferation and inhibits differentiation.Activation of Nfe2l2 (Nrf2) decreases NO production allowing erythroid differentiation.

Keyphrases

nitric oxide
oxidative stress
nitric oxide synthase
hydrogen peroxide
chronic kidney disease
signaling pathway
iron deficiency
stress induced
heat stress