Effects of TRAM-34 and minocycline on neuroinflammation caused by diabetic ketoacidosis in a rat model.

Nicole S GlaserSteven ChuJustin WeinerLinnea ZdepskiHeike WulffDaniel TancrediMartha E ODonnell

Published in: BMJ open diabetes research & care (2022)

These data demonstrate that both TRAM-34 and minocycline reduce acute neuroinflammation during DKA, however, treatment with these agents for 1 week after DKA does not reduce long-term neuroinflammation.

Keyphrases

lipopolysaccharide induced
lps induced
traumatic brain injury
cognitive impairment
cerebral ischemia
inflammatory response
liver failure
electronic health record
respiratory failure
drug induced
clinical trial
combination therapy
blood brain barrier
study protocol
deep learning