BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts.

Tanja SeifritzMatthias BrunnerEva Camarillo RetamosaMalgorzata MaciukiewiczMonika KrošelLarissa MoserThomas ZülligMatija TomšičOliver DistlerCaroline Ospelt Kerstin Klein

Published in: Biomedicines (2023)

BRD3 acts as an upstream regulatory factor that integrates the response to inflammatory stimuli and stress conditions in FLS and executes many functions of BET proteins that have previously been identified using pan-BET inhibitors.

Keyphrases

rheumatoid arthritis
oxidative stress
transcription factor
extracellular matrix
systemic lupus erythematosus