A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction.
Rana El SabehMélanie BonnetKaty Le CorfKevin LangAlain KfouryBassam BadranNader HusseinFrancois VirardIsabelle TreilleuxMuriel Le RomancerSerge LebecqueSerge ManieIsabelle CosteToufic RennoPublished in: Journal of inflammation research (2021)
Collectively, our results indicate that the formation of MyD88/methER-α complexes during inflammatory signaling and their disruption by estrogen may represent a mechanism that contributes to gender bias in inflammatory responses.