Catalyst-Controlled, Enantioselective, and Diastereodivergent Conjugate Addition of Aldehydes to Electron-Deficient Olefins.

S B Jennifer KanHiroki MaruyamaMatsujiro AkakuraTaichi KanoKeiji Maruoka

Published in: Angewandte Chemie (International ed. in English) (2017)

A chiral-amine-catalyzed enantioselective and diastereodivergent method for aldehyde addition to electron-deficient olefins is presented. Hydrogen bonding was used as a control element to achieve unusual anti selectivity, which was further elucidated through mechanistic and computational studies.

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