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Ischemic Stroke After Bivalent COVID-19 Vaccination: Self-Controlled Case Series Study.

Stanley XuLina S SyVennis HongKimberly J HolmquistLei QianPaddy FarringtonKatia J BruxvoortNicola P KleinBruce H FiremanBing HanBruno J Lewin
Published in: JMIR public health and surveillance (2024)
While the point estimate for the risk of chart-confirmed ischemic stroke was elevated in a risk interval of 1-42 days among individuals younger than 65 years with coadministration of Pfizer-BioNTech bivalent and influenza vaccines on the same day and among individuals younger than 65 years who received Moderna bivalent vaccine and had a history of SARS-CoV-2 infection, the risk was not statistically significant. The potential association between bivalent vaccination and ischemic stroke in the 1-42-day analysis warrants further investigation among individuals younger than 65 years with influenza vaccine coadministration and prior SARS-CoV-2 infection. Furthermore, the findings on ischemic stroke risk after bivalent COVID-19 vaccination underscore the need to evaluate monovalent COVID-19 vaccine safety during the 2023-2024 season.
Keyphrases
  • coronavirus disease
  • sars cov
  • atrial fibrillation
  • respiratory syndrome coronavirus
  • climate change