Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement.

Anil SakamuriBruna VisniauskasIsabella Kilanowski-DorohAlexandra B McNallyAriane ImulindeAnne KamauDivya SengottaianJohn McLachlanMontserrat AngueraFranck Mauvais-JarvisSarah H LindseyBernard Ojwang Ogola

Published in: Biology of sex differences (2024)

Testosterone deprivation increases arterial stiffening and vascular wall remodeling. Castration increases Col1α1 in male mice with XX sex chromosome complement. Our study shows decreased aortic contractile genes in castrated mice with XX than XY sex chromosomes.

Keyphrases

replacement therapy
copy number
skeletal muscle
genome wide
aortic valve
left ventricular
heart failure
metabolic syndrome
adipose tissue
dna methylation
insulin resistance
high fat diet induced