Strain-Tunable Microfluidic Devices with Crack and Wrinkle Microvalves for Microsphere Screening and Fluidic Logic Gates.

Mechanical instabilities in soft materials have led to the formation of unique surface patterns such as wrinkles and cracks for a wide range of applications that are related to surface morphologies and their dynamic tuning. Here, we report a simple yet effective strategy to fabricate strain-tunable crack and wrinkle microvalves with dimensions responding to the applied tensile strain. The crack microvalves initially closed before stretching are opened as the tensile strain is applied, whereas the wrinkle microvalves exhibit the opposite trend. Next, the performance of crack and wrinkle microvalves is characterized. The design predictions on the bursting pressure of microvalves and others from the theory agree reasonably well with the experimental measurements. The microfluidic devices with strain-tunable crack and wrinkle microvalves have then been demonstrated for microsphere screening and programmable microfluidic logic devices. The demonstrated microfluidic devices complement the prior studies to open up opportunities in microparticle/cell manipulations, fluidic operations, and biomedicine.