Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot?
Jarmila KnitlovaMartina DoubkovaMartin PlencnerDavid VondrášekAdam EckhardtMartin OstadalJana MusilkovaLucie BačákováTomas NovotnyPublished in: Connective tissue research (2020)
Minoxidil exerts an in vitro inhibitory effect on the cell proliferation, collagen accumulation, and extracellular matrix contraction processes that are associated with clubfoot fibrosis. This study provides important preliminary results demonstrating the potential relevance of MXD for adjuvant pharmacological therapy in standard treatment of relapsed clubfoot.
Keyphrases
- extracellular matrix
- cell proliferation
- acute lymphoblastic leukemia
- multiple myeloma
- diffuse large b cell lymphoma
- induced apoptosis
- early stage
- hodgkin lymphoma
- signaling pathway
- risk assessment
- replacement therapy
- cell death
- smooth muscle
- cell cycle arrest
- oxidative stress
- wound healing
- endoplasmic reticulum stress
- climate change
- cell therapy