CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes.
Brett A SchroederNatalie A LaFranzoBonnie J LaFleurRachel M GittelmanMarissa VignaliShihong ZhangKevin C FlanaganJulie RytlewskiLaura RiolobosBrian C SchulteTeresa S KimEleanor ChenKimberly S SmytheMichael J WagnerJose G MantillaJean S CampbellRobert H PierceRobin L JonesLee D CranmerSeth M PollackPublished in: Journal for immunotherapy of cancer (2021)
Immune cell infiltration predicts clinical outcome in DDLPS, with CD4+ cells associated with better outcomes; CD14+ cells and M2 macrophages are associated with worse outcomes. Future checkpoint inhibitor studies in DDLPS should incorporate immunosequencing and gene expression profiling techniques that can generate immune landscape profiles.