Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome.
Ali AkgulMassimo MaddaloniSang Mu JunAndrew S NelsonVanessa Aguilera OdremanCarol HoffmanElla BhagyarajAlexandria VoigtJeffrey R AbbottCuong Q NguyenDavid W PascualPublished in: Arthritis research & therapy (2021)
These data demonstrate that oral LL-CFA/I reduce or halts SjS progression, and these studies will provide the basis for future testing in SjS patients.