Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group.
Kevin CampbellJulie M Gastier-FosterMeegan MannArlene H NaranjoCollin Van RynRochelle BagatellKatherine K MatthayWendy B LondonMeredith S IrwinHiroyuki ShimadaM Meaghan GrangerMichael D HogartyJulie R ParkSteven G DuBoisPublished in: Cancer (2017)
Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups. Cancer 2017;123:4224-4235. © 2017 American Cancer Society.