Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice.
Shengpan ChenLianhua ZhaoPrativa SherchanYan DingJing YuDerek NowrangiJiping TangYing XiaArne P NeyrinckPublished in: Journal of neuroinflammation (2018)
Our study demonstrated that activation of MC4R with RO27-3225 attenuated neuroinflammation through AMPK-dependent inhibition of JNK and p38 MAPK signaling pathway, thereby reducing brain edema and improving neurobehavioral functions after experimental ICH in mice. Therefore, the activation of MC4R with RO27-3225 may be a potential therapeutic approach for ICH management.
Keyphrases
- signaling pathway
- induced apoptosis
- traumatic brain injury
- skeletal muscle
- lipopolysaccharide induced
- high fat diet induced
- lps induced
- cerebral ischemia
- white matter
- resting state
- oxidative stress
- type diabetes
- protein kinase
- inflammatory response
- insulin resistance
- functional connectivity
- binding protein
- adipose tissue