ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7.

Claudia Garcia-GonzalezChristoph DieterichGiovanni Maroli Marion WiesnetAstrid WietelmannXiang LiXuejun Yuan Johannes Graumann Konstantinos StellosThomas KubinAndre SchneiderThomas Braun

Published in: Circulation research (2022)

Enzymatically active ADAR1 prevents IRF7-mediated autoinflammatory reactions in the heart triggered by endogenous nonedited RNAs. In addition to RNA editing, ADAR1 also serves editing-independent roles in the heart required for long-term cardiac function and survival.

Keyphrases

crispr cas
heart failure
atrial fibrillation
dendritic cells
immune response
nucleic acid