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Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti-PD-L1, for BRCA wild-type, platinum-sensitive, recurrent ovarian cancer.

David G MutchAthina VoulgariXian Marissa ChenWilliam H BradleyAna OakninJosé Alejandro Perez FidalgoFernando Galvez MontosaAntonio Casado HerraezRobert W HollowayMatthew A PowellMalgorzata NowickaGabriele SchaeferMark MerchantYibing Yan
Published in: Cancer (2024)
Chemotherapy-free doublet and triplet therapy demonstrated encouraging activity, including among patients who had BRCA wild-type, HRDsig-positive or HRDsig-negative PSROC harboring NF1 or MKNK1 mutations.
Keyphrases
  • wild type
  • signaling pathway
  • dna damage
  • oxidative stress
  • lps induced
  • dna repair
  • squamous cell carcinoma
  • type diabetes
  • stem cells
  • locally advanced
  • metabolic syndrome
  • nuclear factor
  • mesenchymal stem cells