Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway.

Zhaowei ChenWei LiangJijia HuZijing ZhuJun FengYiqiong MaQian YangGuohua Ding

Published in: Cell proliferation (2022)

Our study has identified Sirt6 as a vital factor that protects against Ang II-induced mitochondrial fission and apoptosis in podocytes via the ROCK1-Drp1 signalling pathway.

Keyphrases

oxidative stress
high glucose
diabetic rats
endothelial cells
ischemia reperfusion injury
diabetic nephropathy
angiotensin ii
drug induced
signaling pathway