Localized Prox1 Regulates Aortic Valve Endothelial Cell Diversity and Extracellular Matrix Stratification in Mice.
Anna O'DonnellBrittany A GonzalezShreyasi MukherjeeRuby WilsonChristina M AlfieriCasey O SwobodaDouglas P MillayAaron M ZornKatherine E YutzeyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our results support a role for Prox1 in localized lymphatic-like gene expression on the fibrosa side of the AoV. Furthermore, localized VEC specialization is required for development of the stratified trilaminar ECM critical for AoV function and is dysregulated in congenitally malformed valves.
Keyphrases
- aortic valve
- extracellular matrix
- gene expression
- aortic valve replacement
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic stenosis
- endothelial cells
- dna methylation
- lymph node
- high fat diet induced
- heart failure
- adipose tissue
- type diabetes
- skeletal muscle
- coronary artery disease
- insulin resistance