Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.

Mohammed E Abo-El Fetoh Maha M Abdel-Fattah Wafaa R Mohamed Laila A A Ramadan Hassan Afify

Published in: Inflammopharmacology (2022)

COX-2 stimulates the ERK1/2 pathway via PGE2-ADAM-17-catalyzed shedding of TGF-α in testosterone-induced BPH. The results indicate a functional correlation between inflammation and hyperplasia in BPH.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
high glucose
signaling pathway
diabetic rats
oxidative stress
small cell lung cancer
replacement therapy
pi k akt
drug induced
epidermal growth factor receptor
endothelial cells
epithelial mesenchymal transition
nitric oxide