The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours.

Arian LundbergLinda S LindströmJingmei LiJ Chuck HarrellEva Darai-RamqvistEmmanouil G SifakisTheodoros FoukakisCharles M PerouKamila CzeneJonas BerghNicholas P Tobin

Published in: Breast cancer research : BCR (2019)

Our results indicate that CCND1 amplification is associated with worse 15-year survival in ER+/LN-/HER2-, luminal A and luminal B patients. Moreover, luminal A CCND1-amplified tumours display gene expression changes consistent with a more aggressive phenotype. These novel findings highlight the potential of CCND1 to identify patients that could benefit from long-term treatment strategies.

Keyphrases

gene expression
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
signaling pathway
cell death
nucleic acid
pi k akt
genome wide analysis