[11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.

Thuy T TranJean-Dominique GallezotLucia B JilaveanuChristopher ZitoGabriela TurcuKeunpoong LimNabeel NabulsiHenry HuangAnita HuttnerHarriet M KlugerVeronica L ChiangRichard Carson

Published in: Molecular imaging (2021)

Sequential use of PET tracers is safe and effective. [11C]Methionine was a reliable TR marker, but [11C]PBR28 was not a reliable marker of RN. Studies are needed to determine the causes of post-radiation inflammation and identify specific markers of RN to improve diagnostic imaging.

Keyphrases

pet imaging
positron emission tomography
high resolution
oxidative stress
squamous cell carcinoma
small cell lung cancer
amino acid
radiation induced
computed tomography
radiation therapy
case control
mass spectrometry
photodynamic therapy