Analysis of Configuration and Conformation of Furanose Ring in Carbohydrate and Nucleoside by Vibrational Circular Dichroism.

Tohru TaniguchiKie NakanoRyosuke BabaKenji Monde

Published in: Organic letters (2017)

A reliable and convenient method for determining the configuration and conformation of the furanose ring in carbohydrates and nucleosides by vibrational circular dichroism (VCD) spectroscopy is described. Diastereomeric pairs of several furanose monosaccharides and nucleosides were prepared, and their VCD spectra were analyzed. The results revealed that VCD spectroscopy elucidates the equibrated state of the furanose ring puckers, which is often difficult to study by other techniques.

Keyphrases

molecular dynamics simulations
density functional theory
high resolution
single molecule
energy transfer
solid state
crystal structure