IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts.
Astrid Van den EyndeLaura GehrckenTias VerhezenHo Wa LauChristophe HermansHilde LambrechtsTal FlieswasserDelphine QuatannensGils RoexKaren ZwaenepoelElly MarcqPhilippe JoyeEdgar Cardenas De La HozChristophe DebenAlessia GaspariniPierre Montay-GruelMaxim Le CompteEva LionFilip LardonSteven Van LaereVasiliki SiozopoulouDiana Campillo-DavoJorrit De WaelePatrick PauwelsJulie JacobsEvelien SmitsJonas R M Van AudenaerdePublished in: Journal of hematology & oncology (2024)
cells. They can target both tumor cells and CAFs in patients with CRC and PDAC, and potentially other desmoplastic solid tumors.