Effects of obesity on reparative function of human adipose tissue-derived mesenchymal stem cells on ischemic murine kidneys.

Nattawat KlomjitSabena M ConleyXiang Yang ZhuIshran M SadiqYaara LibaiJames D KrierChristopher M FergusonKyra L JordanHui TangAmir LermanLilach Orly Lerman

Published in: International journal of obesity (2005) (2022)

Human obesity impairs the reparative properties of adipose-tissue-derived MSCs, possibly by inducing cellular senescence. Dysfunction and senescence of the endogenous MSC repair system in patients with obesity may warrant targeting interventions to restore MSC vitality.

Keyphrases

insulin resistance
adipose tissue
endothelial cells
metabolic syndrome
weight loss
high fat diet induced
type diabetes
high fat diet
weight gain
induced pluripotent stem cells
dna damage
skeletal muscle
physical activity
stress induced
cancer therapy
blood brain barrier