Necrosome-positive granulovacuolar degeneration is associated with TDP-43 pathological lesions in the hippocampus of ALS/FTLD cases.
Evelien Van SchoorM J KoperS OspitalieriLieselot DedeeneS O ToméR VandenbergheD BrennerM OttoJ WeishauptA C LudolphP Van DammeL Van Den BoschDietmar Rudolf ThalPublished in: Neuropathology and applied neurobiology (2020)
Our findings suggest a role for hippocampal TDP-43 pathology as a contributor to necrosome-positive GVD in ALS/FTLD. The absence of necroptosis-related proteins in motor neurons in ALS argues against a role for necroptosis in ALS-related motor neuron death.