Prospective study of germline genetic testing in incident cases of pancreatic adenocarcinoma.

Randall BrandErkut BorazanciVirginia Speare Beth DudleyEve KarloskiMary Linton B PetersLindsey StobieNathan BaharyHerbert ZehAmer ZureikatMelissa HoggKenneth LeeAllan TsungJohn RheeJames OhrWeijing SunJames LeeA James MoserKim DeLeonardisJill KrejdovskyEmily DaltonHolly LaDucaJill DolinskyArlene ColvinCynthia LimMary Helen BlackNadine Tung

Published in: Cancer (2018)

These findings support the significant prevalence of PGVs associated with PDAC and the limitations of current paradigms for selecting patients for genetic testing, and they thereby lend support for universal germline multigene genetic testing in this population.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
dna repair
chronic kidney disease
cardiovascular disease
prognostic factors
risk factors