Association of Apelin Levels in Overweight-obese Children with Pubertal Development, but Not with Insulin Sensitivity: 6.5 Years Follow up Evaluation.
Federica SentinelliLaura BertocciniMichela IncaniMaria Grazia PaniFrancesco DavidDiego BailettAlessandra BoiIlaria BarchettaFlavia Agata CiminiAnna Camilla ManninoAndrea LenziMaria Gisella CavalloSandro LocheEfisio CossuMarco Giorgio BaroniPublished in: Endocrine research (2020)
Apelin levels decrease significantly with pubertal development, whilst body-weight in children and adolescents did not determine changes in apelin. Reduced levels of apelin in children and adolescents may therefore represent a necessary response to maintain the "physiological" insulin resistance of puberty. Abbreviations: ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; G: glucose; BMI: Body mass index; DBP: Diastolic blood pressure; ELISA: enzyme-linked immunosorbent assay; HDL-C: High-density lipoprotein-cholesterol; HOMA-B: Homeostatic model assessment for beta-cell function; HOMA-IR: Homeostatic model assessment of insulin-resistance; INS: Insulin; ISI: insulin-sensitivity index; LDL-C: Low-density lipoprotein cholesterol; NW: normal weight; OB: obese; OGTT: oral glucose tolerance test; OW: overweight; SBP: Systolic blood pressure; TC: Total cholesterol; TGs: Triglycerides.
Keyphrases
- blood pressure
- weight loss
- body mass index
- insulin resistance
- body weight
- weight gain
- type diabetes
- adipose tissue
- metabolic syndrome
- physical activity
- hypertensive patients
- heart rate
- glycemic control
- bariatric surgery
- left ventricular
- high fat diet
- polycystic ovary syndrome
- skeletal muscle
- young adults
- high fat diet induced
- atrial fibrillation
- high density
- ejection fraction
- clinical evaluation