Dual roles of R-loops in the formation and processing of programmed DNA double-strand breaks during meiosis.

Chao LiuWei XuLiying WangZhuo YangKuan LiJun HuYinghong ChenRuidan ZhangSai XiaoWenwen LiuHuafang WeiJia-Yu ChenQianwen SunWei Li

Published in: Cell & bioscience (2023)

Our study reveals that R-loops may play dual roles in meiotic recombination. In addition to participation in meiotic DSB processing, some meiotic DSB hotspots may be originated from the transcription-replication head-on collisions during meiotic DNA replication.

Keyphrases

physical activity
dna damage
transcription factor
circulating tumor
dna repair
circulating tumor cells