The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction.
Jerremy WeertsArantxa Barandiarán AizpuruaMichiel T H M HenkensAurore LyonManouk J W van MourikMathijs R A A van GemertAnne G RaafsSandra Sanders-van WijkAntoni Bayés-GenísStephane R B HeymansHarry J G M CrijnsHans-Peter Brunner-La RoccaJoost LumensVanessa P M van EmpelChristian KnackstedtPublished in: European heart journal. Cardiovascular Imaging (2021)
Mechanical atrial dysfunction has a possible greater prognostic role in HFpEF compared to AF status alone. Mechanical atrial dysfunction is a predictor of adverse outcome independently of AF presence or stage, and may be an underlying mechanism (mediator) for the worse outcome associated with AF in HFpEF. This may suggest mechanical atrial dysfunction plays a crucial role in disease progression in HFpEF patients with AF, and possibly also in HFpEF patients without AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- oxidative stress
- heart failure
- end stage renal disease
- percutaneous coronary intervention
- ejection fraction
- chronic kidney disease
- newly diagnosed
- emergency department
- prognostic factors
- coronary artery disease
- patient reported outcomes
- drug induced