Prophylactic defect closure has been considered to prevent delayed bleeding after polypectomy. However, recent evidence has demonstrated its beneficial effect is limited to those ≥20 mm proximal nonpedunculated lesions. Despite this, prophylactic defect closure is widely performed in clinical practice after colonic endoscopic submucosal dissection (ESD). We present a rare complication of prophylactical clip closure after colonic ESD.