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Triple malignancy (NET, GIST and pheochromocytoma) as a first manifestation of neurofibromatosis type-1 in an adult patient.

Karolina PoredskaLumir KunovskyVladimir ProchazkaJiri DolinaMiroslava ChovancovaJakub VlaznyTomas AndrasinaMichal EidPetr JabandzievPetr KyselaZdenek Kala
Published in: Diagnostic pathology (2019)
NF1 is a rare genetic disease which can cause various benign or malignant tumors. The coincidence of GIST and NET is almost pathognomonic for NF1 and should raise a suspicion of this rare disorder in clinical practice.
Keyphrases
  • signaling pathway
  • clinical practice
  • lps induced
  • pi k akt
  • nuclear factor
  • oxidative stress
  • case report
  • genome wide
  • copy number
  • gene expression
  • cell proliferation
  • dna methylation
  • toll like receptor