Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.

Ryan C MurphyYing LaiMatthew LiuTaha Al-ShaikhlyMatthew C AltmanWilliam A AltemeierCharles W FrevertJason S DebleyAdrian M PiliponskySteven F ZieglerSina A GharibTeal S Hallstrand

Published in: American journal of respiratory and critical care medicine (2023)

Circuits involving epithelial interactions with MCs and EOS are closely associated with indirect AHR. Ex vivo modeling indicates that epithelial-dependent regulation of these innate cells may be critical in indirect AHR and modulating T2 and non-T2 inflammation in asthma.

Keyphrases

innate immune
chronic obstructive pulmonary disease
induced apoptosis
lung function
immune response
oxidative stress
allergic rhinitis
cell therapy
cell cycle arrest
transcription factor
gene expression
signaling pathway
stem cells
cell death
bone marrow
mesenchymal stem cells
heat stress