Clonality, Antigen Recognition, and Suppression of CD8+ T Cells Differentially Affect Prognosis of Breast Cancer Subtypes.
Dora HammerlMaarten P G MassinkMarcel SmidCarolien H M van DeurzenHanne E J Meijers-HeijboerQuinten WaisfiszReno DebetsJohn W M MartensPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Collectively, our data argue that not only CD8 T-cell presence itself, but rather T-cell clonality, T-cell subset distribution, coinhibition, and antigen presentation reflect occurrence of a CD8 T-cell response in breast cancer subtypes, which have been aborted by distinct T-cell-suppressive mechanisms, providing a rationale for subtype-specific combination immune therapies.