Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats.

Csilla Terézia NagyGábor KoncsosZoltán V VargaTamás BaranyaiSebestyén TuzaFerenc KassaiAliz Judit ErnyeyIstván GyertyánKornél KirályAttila OláhTamás RadovitsBéla MerkelyNóra BukoszaGábor SzénásiPéter HamarDomokos MathéKrisztián SzigetiCsilla PelyheMarek JelemenskýZsófia OnódiZsuzsanna HelyesRainer SchulzZoltán GiriczPéter Ferdinandy

Published in: British journal of pharmacology (2018)

Selegiline reduced adiposity, changes in adipose tissue energy metabolism and adipose inflammation induced by HFS diet without affecting the increased body weight, impairment of glucose homeostasis, or behaviour. These results suggest that selegiline could mitigate harmful effects of visceral adiposity.

Keyphrases

insulin resistance
adipose tissue
body weight
high fat diet
metabolic syndrome
skeletal muscle
weight loss
physical activity
type diabetes
oxidative stress
weight gain
body mass index
glycemic control
blood glucose
blood pressure