Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis risk.

David González-SernaChenfu ShiMartin KerickJenny HankinsonJames DingAmanda McGovernMauro TutinoGonzalo Villanueva-MartinNorberto Ortego-CentenoJosé Luis CallejasJavier MartinGisela Orozco

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Our study reveals potential causal genes for SSc-associated loci, some of them acting in a cell type specific manner, suggesting novel biological mechanisms that might mediate SSc pathogenesis.

Keyphrases

genome wide
systemic sclerosis
interstitial lung disease
dna methylation
copy number
genome wide association study
gene expression
dendritic cells
immune response
idiopathic pulmonary fibrosis
transcription factor
bioinformatics analysis