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Optimizing CARs for ocular delivery.

Anandani NellanTerry J Fry
Published in: Nature cancer (2020)
Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.
Keyphrases
  • drug delivery
  • optic nerve
  • oxidative stress
  • diabetic retinopathy
  • high fat diet induced
  • hyaluronic acid
  • protein protein
  • binding protein
  • intensive care unit
  • metabolic syndrome
  • optical coherence tomography