Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1.
Jinhong ZhuKui CaoMeng ZhaoKeru MaXiangyu JiangYuwen BaiXiaodong LingJianqun MaPublished in: Molecular medicine (Cambridge, Mass.) (2023)
The resulting signature from ACK1-related autophagy genes robustly predicted survival and drug sensitivity in LUAD. The lysosomal degradation inhibition improved the therapeutic effects of the ACK1 inhibitor, suggesting a potential role for autophagy in therapy evasion.