The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.
Shima ShahjoueiMohsen Sadeghi-NainiZhihui YangFiras KobeissyDisa RathoreFarhad ShokranehSpiros BlackburnGeoff T ManleyKevin K W WangPublished in: Brain injury (2017)
Traumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the risk of bias according to the QUADAS-2 checklist. A total of 13 reports from 10 original studies were included. Based on our analysis, serum UCH-L1 has a high accuracy in predicting CT findings in mild to moderate TBI. Based on the QUADAS-2 checklist, this result has a high risk of bias affecting its applicability. The plasma level of UCH-L1 has moderate accuracy in predicting CT findings when assessed in all GCS levels. This result has a low risk of bias and low concerns regarding applicability. Pooled analysis suggests that the plasma/serum UCH-L1 level has high accuracy in predicting CT findings in a wide range of GCS in patients with TBI. This result has a high risk of bias and high concern about its applicability. The heterogeneity in approaching TBI biomarker interferes with drawing a definitive conclusion. Therefore, although UCH-L1 is a promising blood-based diagnostic biomarker for TBI, but due to differences in reported diagnostic accuracy, further studies are needed to recommend UCH-L1 as an alternative to CT scanning.
Keyphrases
- traumatic brain injury
- computed tomography
- dual energy
- image quality
- severe traumatic brain injury
- contrast enhanced
- positron emission tomography
- public health
- magnetic resonance imaging
- small molecule
- magnetic resonance
- emergency department
- high resolution
- risk assessment
- radiation therapy
- case control
- social media
- pet ct
- protein protein
- clinical evaluation