NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.

Yizhi ZhanZhanqiao ZhangYuechen LiuYuan FangYuwen XieYilin ZhengGuoxin LiLi LiangYi Ding

Published in: BMC medicine (2022)

Our findings revealed the role of NUPR1 in regulating ROS homeostasis and oxidative stress via the AhR/CYP signal axis upon IR. Strategies targeting the NUPR1/AhR/CYP pathway may have important clinical applications for improving the radiotherapeutic efficacy of HCC.

Keyphrases

dna damage
oxidative stress
cell death
reactive oxygen species
cancer therapy
induced apoptosis
radiation therapy
radiation induced
endoplasmic reticulum stress
heat stress
heat shock protein