The incidence and significance of periictal apnea in epileptic seizures.
Nuria LacueyBilal ZonjyJohnson P HampsonM R Sandhya RaniAnita ZarembaRup K SainjuBrian K GehlbachStephan SchueleDaniel FriedmanOrrin DevinskyMaromi NeiRonald M HarperLuke AllenBeate DiehlJohn J MillichapLisa BatemanMark A GrannerDeidre N DragonGeorge B RichersonSamden D LhatooPublished in: Epilepsia (2018)
ICA is a frequent, self-limiting semiological feature of focal epilepsy, often starting before surface EEG onset, and may be the only clinical manifestation of focal seizures. However, prolonged ICA (≥60 s) is associated with severe hypoxemia and may be a potential SUDEP biomarker. ICA is more frequently seen in temporal than extratemporal seizures, and in typical temporal seizure semiologies. ICA rarely persists after seizure end. ICA agnosia is typical, and thus it may remain unrecognized without polygraphic measurements that include breathing parameters.