Zika virus infection elicits auto-antibodies to C1q.
Takaaki KomaVeljko VeljkovicDanielle E AndersonLin-Fa WangShannan L RossiChao ShanPei-Yong ShiDavid W BeasleyNatalya BukreyevaJeanon N SmithSteven HallamCheng HuangVeronika von MesslingSlobodan PaesslerPublished in: Scientific reports (2018)
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future.
Keyphrases
- zika virus
- dengue virus
- aedes aegypti
- end stage renal disease
- protein protein
- ejection fraction
- newly diagnosed
- amino acid
- binding protein
- prognostic factors
- high resolution
- peritoneal dialysis
- small molecule
- machine learning
- mass spectrometry
- genome wide
- type diabetes
- gene expression
- skeletal muscle
- diabetic rats
- blood brain barrier
- metabolic syndrome
- social media
- density functional theory
- molecular dynamics
- high fat diet induced
- patient reported
- intellectual disability
- data analysis