Gap junction is essential for the antidepressant effects of fluoxetine.

Cong-Yuan XiaNing-Ning ZhangHong JiangYu-Xia LouQian RenXiao-Ling ZhangPeng-Fei YangQian-Hang ShaoHao-Yu ZhuJiang-Fan WanYa-Ni ZhangFang-Fang LiXu YanShi-Feng ChuYi ZhangZhen-Zhen WangNai-Hong Chen

Published in: The Journal of pharmacy and pharmacology (2023)

Our study suggested that gap junction dysfunction blocks antidepressant effects of fluoxetine, contributing to understanding the mechanism underlying the time lag of fluoxetine.

Keyphrases

major depressive disorder
oxidative stress