Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.
Maya MalaabLudivine RenaudNaoko TakamuraKip D ZimmermanWillian A da SilveiraPaula S RamosSandra HaddadMarc Peters-GoldenLoka R PenkeBethany WolfGary HardimanCarl D LangefeldThomas A MedsgerCarol A Feghali-BostwickPublished in: Annals of the rheumatic diseases (2021)
Our data support a role for epigenetic dysregulation in mediating SSc susceptibility in dFBs, illustrating the intricate interplay between CpG methylation, miRNAs and transcription factors in SSc pathogenesis, and highlighting the potential for future use of epigenetic modifiers as therapies.
Keyphrases
- systemic sclerosis
- dna methylation
- transcription factor
- interstitial lung disease
- genome wide
- gene expression
- cell proliferation
- long non coding rna
- electronic health record
- long noncoding rna
- current status
- big data
- dna binding
- human health
- extracellular matrix
- pulmonary fibrosis
- rheumatoid arthritis
- wound healing
- artificial intelligence
- genome wide identification
- data analysis