NOX4-Derived ROS Promotes Collagen I Deposition in Bronchial Smooth Muscle Cells by Activating Noncanonical p38MAPK/Akt-Mediated TGF-β Signaling.

Binwei HaoRuiting SunXiaotong GuoLili ZhangJieda CuiYumin ZhouWei HongYanan ZhangJinxi HeXiaoming LiuBing LiPixin Ran Juan Chen

Published in: Oxidative medicine and cellular longevity (2021)

NOX4-mediated ROS production alters TGF-β 1-induced cell differentiation and collagen I protein synthesis in HBSMCs in part through the p38MAPK/Akt signaling pathway in a Smad-dependent manner.

Keyphrases

signaling pathway
transforming growth factor
reactive oxygen species
epithelial mesenchymal transition
pi k akt
cell death
induced apoptosis
dna damage
cell proliferation
high glucose
diabetic rats
wound healing
tissue engineering