Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.

Kristine PettersenSonja AndersenAnna van der VeenUnni NonstadShinji HatakeyamaChristian LambertEstelle Lach-TrifilieffSiver MoestueJana KimBjørn Henning GrønbergAlain SchilbCarsten JacobiGeir Bjørkøy

Published in: Journal of cachexia, sarcopenia and muscle (2019)

Our data support a functional link between activin A and IL-6 signalling pathways and indicate that interference with activin A-induced IL-6 secretion from the tumour has therapeutic potential for cancer-induced cachexia.

Keyphrases

high glucose
diabetic rats
oxidative stress
cell death
drug induced
signaling pathway
big data
artificial intelligence