JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis.

Maria Rosa CiardiMaria Antonella ZingaropoliMarco IannettaCarla PreziosoValentina PerriPatrizia PasculliMiriam LichtnerGabriella d'EttorreMarta AltieriAntonella ConteValeria PietropaoloClaudio Maria MastroianniVincenzo Vullo

Published in: Virology journal (2020)

The comparison of HIV-positive and HIV-negative MS patients with PML, allowed us to evidence the presence of a common pattern of JCPyV NCCR rearrangement, characterized by the deletion of the D-block, which could be one of the initial rearrangements of JCPyV NCCR needed for the development of PML.

Keyphrases

hiv positive
antiretroviral therapy
men who have sex with men
south africa
risk factors
hiv testing
hiv infected
human immunodeficiency virus
mass spectrometry
hiv aids
multiple sclerosis
hepatitis c virus